In Vivo Molecular Mri of Atherosclerotic Plaque Progression in Mice Using a Novel Elastin-binding Contrast Agent
نویسندگان
چکیده
M. R. Makowski, U. Blume, A. J. Wiethoff, C. Jansen, J. Lazewatsky, S. Robinson, and R. M. Botnar King’s College London BHF Centre of Research Excellence, Imaging Sciences Division, London, London, United Kingdom, King’s College London BHF Centre of Research Excellence, Imaging Sciences Division, London, United Kingdom, Lantheus Medical Imaging, United States, King’s College London BHF Centre of Research Excellence, Imaging Sciences Division, United Kingdom
منابع مشابه
In Vivo Detection of Activated Platelets Allows Characterizing Rupture of Atherosclerotic Plaques with Molecular Magnetic Resonance Imaging in Mice
BACKGROUND Early and non-invasive detection of platelets on micro atherothrombosis provides a means to identify unstable plaque and thereby allowing prophylactic treatment towards prevention of stroke or myocardial infarction. Molecular magnetic resonance imaging (mMRI) of activated platelets as early markers of plaque rupture using targeted contrast agents is a promising strategy. In this stud...
متن کاملEvaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach.
OBJECTIVE Despite great advances in our knowledge, atherosclerosis continues to kill more people than any other disease in the Western world. This is because our means of identifying truly vulnerable patients is limited. Prediction of atherosclerotic plaque rupture may be addressed by MRI of activated matrix metalloproteinases (MMPs), a family of enzymes that have been implicated in the vulnera...
متن کاملMolecular MRI of Inflammation in Atherosclerosis
Inflammatory activity in atherosclerotic plaque is a risk factor for plaque rupture and atherothrombosis and may direct interventional therapy. Inflammatory activity can be evaluated at the (sub)cellular level using in vivo molecular MRI. This paper reviews recent progress in contrast-enhanced molecular MRI to visualize atherosclerotic plaque inflammation. Various MRI contrast agents, among oth...
متن کاملMRI of Coronary Wall Remodeling in a Swine Model of Coronary Injury using an Elastin-Binding Contrast Agent Running Title: von Bary et al: MRI of Coronary Wall Using an Elastin Specific Compound
Background The extracellular matrix (ECM) plays an important role in the pathogenesis of atherosclerosis and in-stent-restenosis. Elastin is an essential component of the ECM. ECM degradation can lead to plaque destabilization while enhanced synthesis typically leads to vessel wall remodeling resulting in arterial stenosis or in-stent-restenosis following stent implantation. The objective of th...
متن کاملMolecular and cellular targets of the MRI contrast agent P947 for atherosclerosis imaging.
P947 (DOTA-Gd-peptide) was recently identified as an MRI contrast agent for the detection and characterization of the matrix metalloproteinases (MMP)-rich atherosclerotic plaques. Because this product displays a broad spectrum affinity for the MMP family, we hypothesized that it may also recognize other metalloproteinases overactivated in vulnerable atherosclerotic plaques. Therefore, this stud...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008